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There are 8 ten-letter words containing 2I, O, 2T and X

ANTITOXINSantitoxins n. Plural of antitoxin.
ANTITOXIN n. an antidote to a toxin.
EXCITATIONexcitation n. The act of exciting or putting in motion; the act of rousing up or awakening.
excitation n. The act of producing excitement (stimulation); also, the excitement produced.
excitation n. (Physiology) The activity produced in an organ, tissue, or part, such as a nerve cell, as a result of stimulation.
EXOTICISTSexoticists n. Plural of exoticist.
EXOTICIST n. an enthusiast for the exotic.
EXTINCTIONextinction n. The action of making or becoming extinct; annihilation.
extinction n. (Astronomy) The absorption or scattering of electromagnetic radiation emitted by astronomical objects…
extinction n. (Pathology) The inability to perceive multiple stimuli simultaneously.
INTOXICANTintoxicant n. Something which intoxicates; an intoxicating agent.
intoxicant n. Poison.
intoxicant adj. Intoxicating.
INTOXICATEintoxicate v. To stupefy by doping with chemical substances such as alcohol.
intoxicate v. To excite to enthusiasm or madness.
intoxicate adj. (Obsolete) Intoxicated.
TOXICATIONtoxication n. (Biochemistry) the metabolism of a drug or other compound to produce a toxic metabolite.
TOXICATION n. the state of being toxic.
TOXICITIEStoxicities n. Plural of toxicity.
TOXICITY n. the state of being toxic.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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