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There are 9 eight-letter words containing 2I, O, T and Z

EPIZOITEepizoite n. Any epizoic organism.
EPIZOITE n. an epizoic organism.
OPTIMIZEoptimize v. (Originally intransitive) To act optimistically or as an optimist.
optimize v. (Transitive) To make (something) optimal.
optimize v. (Transitive) To make (something) more efficient, such as a computer program.
RIOTIZESRIOTIZE n. (obsolete) riot, extravagance, also RIOTISE.
ROZITINGROZIT v. (Scots) to rosin, also ROSET, ROSIT, ROZET.
ZEOLITICzeolitic adj. Of, pertaining to, containing, or produced using a zeolite.
ZEOLITIC adj. of or pertaining to a zeolite.
ZOIATRIAzoiatria n. (Archaic) veterinary medicine.
ZOIATRIA n. (Greek) veterinary surgery.
ZOISITESzoisites n. Plural of zoisite.
ZOISITE n. a silicate of calcium and aluminium.
ZOOLITICzoolitic adj. Relating to zoolites.
ZOOLITIC adj. of or like a zoolite, a fossil animal.
ZOONITICzoonitic adj. Relating to a zoonite.
ZOONITIC adj. like a zoonite, one of the segments of the body of an articulate animal.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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