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There are 3 seven-letter words containing 2I, 2O and S

OPIOIDSopioids n. Plural of opioid.
OPIOID n. a peptide that acts like opium.
PIOPIOSpiopios n. Plural of piopio.
PIOPIO n. (Maori) a New Zealand thrush, thought to be extinct.
TOITOISTOITOI n. (Maori) a tall reedlike grass of New Zealand, also TOETOE.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the 1Word.ws and WikWik.org.

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