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There are 20 twelve-letter words containing I, M, 2S and X

BISEXUALISMSBISEXUALISM n. being bisexual.
CHEMOTAXISESCHEMOTAXIS n. orientation of an animalcule relative to a chemical substance.
EXCLUSIONISMexclusionism n. The quality of being exclusionist.
exclusionism n. A policy or ideology that favors exclusion of some individuals or groups from a nation, sect, etc.
EXCLUSIONISM n. the practice of excluding others from some right or privilege.
EXCLUSIVISMSexclusivisms n. Plural of exclusivism.
EXCLUSIVISM n. the practice of excluding or of being exclusive.
EXOTERICISMSEXOTERICISM n. the state of being exoteric.
EXPANSIONISMexpansionism n. The policy, of a nation, of expanding its territory or its economic influence.
EXPANSIONISM n. a policy or practice of expansion and esp. of territorial expansion by a nation.
EXPROMISSIONexpromission n. (Law) The intervention of a new debtor, substituted for the former one, who is consequently discharged…
EXPROMISSION n. relieving another person's debt by taking it upon oneself.
EXPROMISSORSexpromissors n. Plural of expromissor.
EXPROMISSOR n. a person relieving another of debt by taking it upon himself.
EXTEMPORISESextemporises v. Third-person singular simple present indicative form of extemporise.
EXTEMPORISE v. to perform without preparation or practice; to improvise, also EXTEMPORIZE.
EXTERNALISMSexternalisms n. Plural of externalism.
EXTERNALISM n. undue regard to mere externals or nonessential outward forms, esp. of religion.
HETEROSEXISMheterosexism n. The assumption made when relating to others that everyone is heterosexual.
heterosexism n. Discrimination or prejudice in favor of heterosexuals.
HETEROSEXISM n. the belief that homosexuality is a perversion.
HEXAMETRISESHEXAMETRISE v. to put into hexameters, also HEXAMETRIZE.
HEXAMETRISTShexametrists n. Plural of hexametrist.
HEXAMETRIST n. a writer of hexameters.
MOXIBUSTIONSmoxibustions n. Plural of moxibustion.
MOXIBUSTION n. cauterization by use of moxa.
PANSEXUALISMpansexualism n. (Psychology, historical) The psychological theory that all human activity (mental and physical) is based on sexuality.
pansexualism n. (Rare, chiefly derogatory) Pansexuality.
PANSEXUALISM n. the theory that all thought derives from the sexual instinct.
SEXAGESIMALSsexagesimals n. Plural of sexagesimal.
SEXAGESIMAL n. a sexagesimal fraction.
SEXTODECIMOSsextodecimos n. Plural of sextodecimo.
SEXTODECIMO n. a book size 5 5/8 in. x 4 3/8 in. (abbreviated as 16mo.), also SIXTEENMO.
TAXIDERMISESTAXIDERMISE v. to practise taxidermy, also TAXIDERMIZE.
TAXIDERMISTStaxidermists n. Plural of taxidermist.
TAXIDERMIST n. one who practises taxidermy.
XEROPHYTISMSXEROPHYTISM n. being a xerophyte.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the 1Word.ws and WikWik.org.

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