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There are 16 eight-letter words containing 2I, P and X

AMPHIOXIamphioxi n. Plural of amphioxus.
AMPHIOXUS n. (Greek) a fishlike creature, two or three inches long, found in temperate seas, aka lancelet.
APOMIXISapomixis n. (Botany) Plant reproduction without fertilization.
apomixis n. (Botany) Plant reproduction without fertilization, meiosis, or the production of gametes.
apomixis n. (Zoology) Animal reproduction in which the egg cell does not undergo meiosis or fertilization.
EPITAXICepitaxic adj. Relating to epitaxy.
EPITAXIC adj. relating to epitaxy, the growth of a thin layer of crystals on another crystal so that they have the same structure, also EPITAXIAL.
EPITAXISEPITAXIS n. the part of a play in which the main action develops, also EPITASIS.
EXPIRIESexpiries n. Plural of expiry.
EXPIRY n. expiration; death.
EXPIRINGexpiring adj. Ending, terminating, dying.
expiring v. Present participle of expire.
EXPIRE v. to come to an end.
EXPLICITexplicit adj. Very specific, clear, or detailed.
explicit adj. (Euphemistic) Containing material (e.g. language or film footage) that might be deemed offensive or graphic.
explicit n. The final few words of a text.
MIREPOIXmirepoix n. A combination of diced onions, carrots, celery and herbs sautéed in oil or butter as used in French cooking.
mirepoix n. (Figurative) A mixture.
Mirepoix prop.n. A city in the Ariège department, France.
PANMIXIApanmixia n. (Ecology) A situation in which an individual is just as likely to mate with a randomly chosen individual…
panmixia n. (Biology) The cessation of natural selection, as on a useless organ.
PANMIXIA n. random mating within a breeding population, also PANMIXIS.
PANMIXISpanmixis n. (Ecology) Panmixia.
PANMIXIS n. (Greek) random mating within a breeding population, also PANMIXIA.
PIXIEISHpixieish adj. Alternative spelling of pixyish.
PIXIEISH adj. like a pixie.
PIXILATEpixilate v. Misspelling of pixelate.
PIXILATE v. to divide an image into pixels for display in a digital format, also PIXELATE, PIXELLATE, PIXILLATE.
PIXINESSpixiness n. Quality of being pixyish.
PIXINESS n. the state of being playfully mischievous.
PYXIDIUMpyxidium n. (Botany) A seed capsule in the form of a box, the seeds being released when the top splits off.
PYXIDIUM n. a capsule that opens by a transverse circular split.
SPINIFEXspinifex n. An Australian coastal grass, in genus Spinifex.
spinifex n. (Australia) A coastal grass, either in genera Triodia or Spinifex.
SPINIFEX n. (Latin) a sharp-pointed Australian grass.
XIPHOIDSxiphoids n. Plural of xiphoid.
XIPHOID n. the xiphoid process or xiphisternum.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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