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There are 3 six-letter words containing 2I and 2O

OPIOIDopioid n. A substance that has effects similar to opium.
opioid n. (Physiology) Any of the natural substances, such as an endorphin, released in the body in response to pain.
opioid n. (Pharmacology) Any of a group of synthetic compounds that exhibit similarities to the opium alkaloids…
PIOPIOpiopio n. Either of two extinct passerine songbirds of New Zealand comprising the genus Turnagra: the North Island…
PIOPIO n. (Maori) a New Zealand thrush, thought to be extinct.
TOITOItoitoi n. Alternative form of toetoe.
TOITOI n. (Maori) a tall reedlike grass of New Zealand, also TOETOE.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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