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There are 17 five-letter words containing I, O, P and S

DIPSOdipso n. (Informal) A dipsomaniac; an alcoholic; a drunk.
dipso- pref. Thirst; drinking.
DIPSO n. (short for) a dipsomaniac, one addicted to drink.
INSPOinspo n. (Slang) Clipping of inspiration.
INSPO n. someone or something that is a source of inspiration.
LIPOSLIPO n. (colloquial) a liposuction.
OPSINopsin n. (Biochemistry) Any of a group of light-sensitive proteins in the retina.
OPSIN n. a protein which forms part of the visual pigment rhodopsin.
PIONSpions n. Plural of pion.
PION n. an elementary particle of the meson family.
PIOUSpious adj. Of or pertaining to piety, exhibiting piety, devout, godfearing.
pious adj. Relating to religion or religious works.
pious adj. Insisting on or making a show of one’s own virtue, especially in comparison to others; sanctimonious…
PIOYSPIOY n. (Scots) a homemade firework, also PEEOY, PIOYE.
PISCOpisco n. A liquor distilled from grapes (a brandy) made in wine-producing regions of Peru and Chile. It is the…
Pisco n. A kind of brandy produced in Peru and Chile.
PISCO n. a Peruvian brandy.
PISOSPISO n. (Tagalog) the Philippines peso.
POISEpoise n. A state of balance, equilibrium or stability.
poise n. Composure; freedom from embarrassment or affectation.
poise n. Mien; bearing or deportment of the head or body.
POLISpolis n. (Historical) A Greek city-state.
polis n. (Uncountable, Scotland, Ireland, Geordie) The police.
polis n. (Countable, Scotland, Ireland, Geordie) A police officer.
POSITposit n. Something that is posited; a postulate.
posit n. (Aviation) Abbreviation of position.
posit v. Assume the existence of; to postulate.
PSIONpsion n. The psi-meson, a sub-atomic particle.
psion n. A person with psionic abilities.
PSION n. a particle formed by collision of a positron and an electron.
PSOAIpsoai n. Plural of psoas.
PSOAS n. (Greek) a muscle of the pelvic region.
SPOILspoil v. (Transitive, archaic) To strip (someone who has been killed or defeated) of their arms or armour.
spoil v. (Transitive, archaic) To strip or deprive (someone) of their possessions; to rob, despoil.
spoil v. (Transitive, intransitive, archaic) To plunder, pillage (A city, country etc.).
TOPIStopis n. Plural of topi.
TOPI n. (Hindi) a tropical pith helmet, also TOPEE.
VOIPSVOIP n. a system for converting analogue signals to digital so that telephone calls may be made over the internet (Voice Over Internet Protocol).

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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