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There are 4 five-letter words containing I, 2O and T

NOOITnooit adv. (South Africa) never; no way.
NOOIT interj. (South African) expressing pleased or shocked surprise.
OOBIToobit n. (Obsolete, Northern England) A caterpillar.
OOBIT n. a hairy caterpillar, esp. of the tiger moth, also OUBIT, WOOBUT, WOUBIT.
OOTIDootid n. (Biology) The haploid cell, produced by meiotic division of a secondary oocyte, that is a nearly mature ovum.
oötid n. Alternative spelling of ootid.
OOTID n. one of the four sections into which a mature ovum divides.
TOPOItopoi n. Plural of topos.
TOPOS n. (Greek) a stock theme or topic.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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