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There are 19 four-letter words containing I, O and S

BIOSbios n. Plural of bio.
bios n. (Obsolete) A vitamin essential for the growth of yeast, since found to be several B vitamins.
bios n. In the philosophy of Giorgio Agamben, a particular mode of life; "qualified life", as opposed to the bare life or zoe.
BOISbois n. Plural of boi.
Bois prop.n. A surname from French.
Bois prop.n. Alternative form of Dubois.
GIOSGIO n. a gully or creek, also GEO, GOE.
HOISHOI v. to urge, incite.
IONSions n. Plural of ion.
Ions prop.n. A surname originating as a patronymic.
Ions prop.n. Plural of Ion.
ISOSisos n. Plural of iso.
ISOs n. Plural of ISO.
ISO n. (short for) an isolated replay, a TV and film facility.
KOISKOIs n. Plural of KOI.
KOI n. (Japanese) a large Japanese carp.
MISOmiso n. A thick paste made by fermentation of soybeans with the mold Aspergillus oryzae, used in making soups and sauces.
miso- pref. Hatred; dislike; aversion.
MISO n. (Japanese) a paste, used in flavouring, prepared from soya beans and fermented in brine.
OBISobis n. Plural of obi.
OBI v. to bewitch.
OIKSoiks n. Plural of oik.
OIK n. an inferior person.
OILSoils n. Plural of oil.
oils v. Third-person singular simple present indicative form of oil.
OIL v. to lubricate with a greasy substance.
PISOPISO n. (Tagalog) the Philippines peso.
POISpois n. Plural of poi.
Pois sym. (Mathematics, statistics) Poisson distribution.
POIs n. Plural of POI.
SIJOsijo n. A classical Korean poetry form consisting of twelve accentual phrases divided in three lines.
sijo n. Non-Korean poetry written in imitation of this style.
sijo n. The musical mode to which these works were traditionally sung.
SILOsilo n. (Agriculture) A vertical building, usually cylindrical, used for the production of silage.
silo n. (Agriculture) from the shape, a building used for the storage of grain.
silo n. (Military) An underground bunker used to hold missiles which may be launched.
SKIOskio n. Alternative form of skeo.
SKIO n. (Orkney) a hut, a shed, also SKEO.
SOILsoil n. (Uncountable) A mixture of mineral particles and organic material, used to support plant growth.
soil n. (Uncountable) The unconsolidated mineral or organic material on the immediate surface of the earth that…
soil n. (Uncountable) The unconsolidated mineral or organic matter on the surface of the earth that has been…
SOLIsoli n. (Music) plural of solo.
Soli prop.n. A surname from Italian.
Sol␣I prop.n. (Astronomy) The planet Mercury.
SORIsori n. (Botany) plural of sorus.
sori n. (Obsolete) copper sulphate.
SORUS n. (Greek) a cluster of sporangia.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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