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There are 7 four-letter words containing 2I and S

IBISibis n. Any of various long-legged wading birds in the family Threskiornithidae, having long downcurved bills…
IBIS n. any of a group of gregarious wading birds of warm and tropical climates.
IRISiris n. (Botany) A plant of the genus Iris, common in the northern hemisphere, and generally having attractive…
iris n. (Anatomy) The contractile membrane perforated by the pupil, which adjusts to control the amount of light…
iris n. (Photography, cinematography) A diaphragm used to regulate the size of a hole, especially as a way of…
ISITis␣it interj. Used other than figuratively or idiomatically: see is, it.
is␣it interj. (Canada, South Africa, Indian English, MLE, MTE) really? is that so?
is␣it part. (Singapore, Wales) Final interrogative particle forming a tag question.
IWISiwis adv. (Poetic, archaic) Certainly, surely, indeed.
I␣wis adv. Assuredly, truly, indeed.
IWIS adv. certainly, also YWIS.
NISInisi n. (Attributive) decree nisi.
NISI adj. (Latin) taking effect at a specified date unless cause is shown otherwise, as in decree nisi.
SIMIsimi n. A short sword or dagger used by the Kikuyu people.
simi pron. (Interrogative) what.
simi pron. Anything; whatever.
SIRIsiri n. Alternative form of sirih (“plant”).
Siri prop.n. A female given name.
Siri prop.n. (Computing) A speech recognition and intelligent personal assistant application developed by Apple Inc…

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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