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There are 2 two-letter words containing I and S

ISis v. Third-person singular simple present indicative form of be.
is v. (Now colloquial) Used in phrases with existential there when the semantic subject is a third-person plural.
is pron. (Geordie) Alternative spelling of us (“me”).
SIsi n. (Music) A syllable used in solfège to represent the seventh note of a major scale.
si sym. (International standards) ISO 639-1 language code for Sinhalese.
Si prop.n. A diminutive of the male given name Simon.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org.

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