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There are 12 words containing H, 2I, O, 2S and X

PHOENIXISMSPHOENIXISM n. the practice of forming a new company with same directors, workforce etc. from a bankrupt company.
ASPHYXIATIONSasphyxiations n. Plural of asphyxiation.
ASPHYXIATION n. the act of asphyxiation.
PHOTOOXIDISESPHOTOOXIDISE v. to undergo photooxidation, also PHOTOOXIDIZE.
SEXTILLIONTHSsextillionths n. Plural of sextillionth.
SEXTILLIONTH n. the ordinal of a sextillion, a thousand raised to the seventh power.
EXHIBITIONISMSexhibitionisms n. Plural of exhibitionism.
EXHIBITIONISM n. extravagant behaviour aimed at drawing attention to oneself.
EXHIBITIONISTSexhibitionists n. Plural of exhibitionist.
EXHIBITIONIST n. one who engages in exhibitionism.
HEXOSAMINIDASEhexosaminidase n. (Biochemistry) Any enzyme that catalyzes the hydrolysis of terminal hexosamine residues in hexosaminides.
HEXOSAMINIDASE n. either of two hydrolytic enzymes that catalyze the splitting off of a hexose from a ganglioside and are deficient in some metabolic diseases.
THYROTOXICOSISthyrotoxicosis n. (Medicine) The medical condition caused by the state of raised levels of thyroid hormone.
THYROTOXICOSIS n. hyperthyroidism with goitre and exophthalmia, Graves' disease.
HEXOSAMINIDASEShexosaminidases n. Plural of hexosaminidase.
HEXOSAMINIDASE n. either of two hydrolytic enzymes that catalyze the splitting off of a hexose from a ganglioside and are deficient in some metabolic diseases.
HIERACOSPHINXEShieracosphinxes n. Plural of hieracosphinx.
HIERACOSPHINX n. in ancient Egyptian art, a hawk-headed sphinx.
HOMOSEXUALITIEShomosexualities n. Plural of homosexuality.
HOMOSEXUALITY n. the state of being homosexual.
LEXICOGRAPHISTSlexicographists n. Plural of lexicographist.
LEXICOGRAPHIST n. one who makes dictionaries.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the 1Word.ws and WikWik.org.

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