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There are 4 ten-letter words containing H, 2I, O and 3S

HISTOLYSIShistolysis n. Breakdown of bodily tissues.
HISTOLYSIS n. the decay and dissolution of the organic tissues and of the blood.
HISTORISMShistorisms n. Plural of historism.
HISTORISM n. the belief that all phenomena are historically determined, also HISTORICISM.
RHOICISSUSRhoicissus prop.n. A taxonomic genus within the family Vitaceae – an Afrotropical plant genus.
RHOICISSUS n. a genus of climbing plants, including the grape ivy.
VICHYSSOISVICHYSSOIS adj. (French) of the Vichyite government.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the 1Word.ws and WikWik.org.

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