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There are 6 ten-letter words containing H, 2I, L, O and 2S

HISTOLYSIShistolysis n. Breakdown of bodily tissues.
HISTOLYSIS n. the decay and dissolution of the organic tissues and of the blood.
ISOCHIMALSISOCHIMAL n. an isochimal line, also ISOCHEIMAL.
LIONFISHESlionfishes n. Plural of lionfish.
LIONFISH n. a tropical fish.
PHOLIDOSISpholidosis n. The pattern made by the scales of a reptile.
PHOLIDOSIS n. the arrangement of scales, as in fish and reptiles.
POLISHINGSpolishings n. Plural of polishing.
POLISHING n. the act of polishing.
SIALOLITHSsialoliths n. Plural of sialolith.
SIALOLITH n. a calculus in a salivary gland.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the 1Word.ws and WikWik.org.

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