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There are 20 twelve-letter words containing H, O, S, T and 2U

BUTTONBUSHESbuttonbushes n. Plural of buttonbush.
BUTTONBUSH n. a North American shrub of the madder family with globular flower heads.
CUSTOMHOUSEScustomhouses n. Plural of customhouse.
custom␣houses n. Plural of custom house.
CUSTOMHOUSE n. an office or residence for customs officials, also CUSTOMSHOUSE.
CUSTOMSHOUSEcustomshouse n. Alternative form of custom house.
customs␣house n. Alternative form of custom house.
CUSTOMSHOUSE n. an office or residence for customs officials, also CUSTOMHOUSE.
EURYTHERMOUSeurythermous adj. Synonym of eurythermal.
EURYTHERMOUS adj. tolerating a wide range of temperature, also EURYTHERMAL, EURYTHERMIC.
HEBETUDINOUShebetudinous adj. Displaying mental lethargy or dullness.
HEBETUDINOUS adj. dull or lethargic, esp. relating to the mind.
MULTIAUTHORSSorry, definition not available.
OUTTHRUSTINGoutthrusting v. Present participle of outthrust.
OUTTHRUST v. to extend outwards.
POSTHUMOUSLYposthumously adv. After death.
post-humously adv. Alternative spelling of posthumously.
POSTHUMOUS adv. taking place after death.
SLAUGHTEROUSslaughterous adj. Prone to slaughtering.
SLAUGHTEROUS adj. of or relating to slaughter.
SLEUTHHOUNDSsleuthhounds n. Plural of sleuthhound.
sleuth-hounds n. Plural of sleuth-hound.
SLEUTHHOUND n. a bloodhound; (colloquial) a detective.
SULPHURATIONsulphuration n. Alternative form of sulfuration.
SULPHURATION n. the act of sulphurating, also SULFURATION.
SULPHURATORSsulphurators n. Plural of sulphurator.
SULPHURATOR n. a device for sulphurating.
SULPHURWORTSsulphurworts n. Plural of sulphurwort.
SULPHURWORT n. an umbelliferous plant akin to parsnip, with yellow flowers and juice.
THIOSULFURICthiosulfuric adj. (Inorganic chemistry) Of or pertaining to thiosulfuric acid or its derivatives.
THIOSULFURIC adj. as in thiosulfuric acid, an unstable acid known only in solutions and in the form of its salts.
THROUGHGAUNSTHROUGHGAUN n. (Scots) a scolding.
THUNDEROUSLYthunderously adv. In a thunderous manner, very loudly.
THUNDEROUS adv. sounding like thunder, also THUNDROUS.
UNAUTHORISEDunauthorised adj. Not authorised; having no authority.
UNAUTHORISED adj. not authorised, also UNAUTHORIZED.
UNCOQUETTISHuncoquettish adj. Not coquettish.
UNCOQUETTISH adj. not coquettish.
UNTOUCHABLESuntouchables n. Plural of untouchable.
UNTOUCHABLE n. one that is untouchable, esp. a Hindu of very low caste.
YOUTHFULNESSyouthfulness n. The vitality characteristic of youth.
YOUTHFULNESS n. the state of being youthful.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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