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There are 4 six-letter words containing H, O, P, S and U

HOPPUShoppus n. A unit of measure of volume equal to 1.273 cubic feet or 2,200 cubic inches. Used in the British Empire…
Hoppus prop.n. A surname.
HOPPUS adj. as in hoppus foot, a unit of volume for round timber.
OUPHESouphes n. Plural of ouphe.
OUPHE n. (Shakespeare) an oaf, a changeling, also OUPH.
TOPHUStophus n. (Medicine) A deposit of monosodium urate crystals in the body, caused by high levels of uric acid in the blood.
TOPHUS n. (Latin) a deposit of urates in the tissue around a joint.
UPSHOTupshot n. The final result, or outcome of something.
upshot n. (US) A concise summary.
upshot n. (US) A positive aspect or consequence, often either unexpected or in contrast to other negative aspects.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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