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There are 16 twelve-letter words containing H, O, 2T and X

ANTHOXANTHINanthoxanthin n. (Biochemistry) Any of a group of water-soluble flavonoid pigments found in plants.
ANTHOXANTHIN n. a yellow pigment in plants.
CHATTERBOXESchatterboxes n. Plural of chatterbox.
CHATTERBOX n. a talkative person.
ETHOXYETHANEethoxyethane n. (Organic chemistry, systematic name) diethyl ether.
ETHOXYETHANE n. a type of ether, aka diethyl ether, an isomer of butanol.
EXHORTATIONSexhortations n. Plural of exhortation.
EXHORTATION n. an act or instance of exhorting.
HETEROSEXISTheterosexist n. A homophobic heterosexual person.
HETEROSEXIST n. one who believes that homosexuality is a perversion.
HETEROTAXIASHETEROTAXIA n. the abnormal disposition of organs or parts, also HETEROTAXY.
HETEROTAXIESHETEROTAXY n. the abnormal disposition of organs or parts, also HETEROTAXIA.
METATHORAXESmetathoraxes n. Plural of metathorax.
METATHORAX n. the last or posterior segment of the thorax in insects.
METHOTREXATEmethotrexate n. (Pharmacology) An antimetabolite and antifolate drug used in treatment of cancer and autoimmune diseases.
METHOTREXATE n. a drug used in the treatment of cancer.
PHOTOEXCITEDphotoexcited v. Simple past tense and past participle of photoexcite.
photoexcited adj. (Chemistry, physics) (of an atom, molecule or ion) excited due to photoexcitation.
PHOTOEXCITED adj. relating to photoexcitation.
SEXTILLIONTHsextillionth adj. The ordinal form of the number one sextillion.
sextillionth n. The person or thing in the sextillionth position.
sextillionth n. One of a sextillion equal parts of a whole.
THIXOTROPIESTHIXOTROPY n. the property of certain gels of becoming fluid when agitated and of reverting back to a gel when left to stand.
TOXOPHILITEStoxophilites n. Plural of toxophilite.
TOXOPHILITE n. one fond of or expert at archery.
TOXOPHILITICtoxophilitic adj. Relating to archery.
TOXOPHILITIC adj. related to archery.
XANTHOMATOUSxanthomatous adj. Of or relating to xanthoma or xanthomatosis.
XANTHOMATOUS adj. of or like a xanthoma, a skin disease marked by the development or irregular yellowish patches upon the skin.
XANTHOPTERINxanthopterin n. A yellow crystalline solid that occurs mainly in the wings of butterflies and in the urine of mammals…
XANTHOPTERIN n. a yellow pigment obtainable from the wings of yellow butterflies and the urine of mammals, also XANTHOPTERINE.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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