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There are 20 eight-letter words containing H, I, S and X

ASPHYXIAasphyxia n. Loss of consciousness due to the interruption of breathing and consequent anoxia.
asphyxia n. Loss of consciousness due to the body’s inability to deliver oxygen to its tissues, either by the breathing…
asphyxia n. (Medicine, obsolete) A condition in which an extreme decrease in the concentration of oxygen in the…
CATHEXIScathexis n. (Psychoanalysis) The concentration of libido or emotional energy on a single object or idea.
CATHEXIS n. (Greek) the investment of emotional energy in a thought or idea.
CHENIXESchenixes n. Plural of chenix.
CHENIX n. (Greek) an ancient Greek dry measure.
ETHOXIESethoxies n. Plural of ethoxy.
ETHOXY n. a univalent chemical radical, also ETHOXYL.
EXHIBITSexhibits n. Plural of exhibit.
exhibits v. Third-person singular simple present indicative form of exhibit.
EXHIBIT v. to display publicly.
FOXSHIPSFOXSHIP n. (Shakespeare) craftiness.
HEXEREIShexereis n. Plural of hexerei.
HEXEREI n. (German) witchcraft.
HYPOXIAShypoxias n. Plural of hypoxia.
HYPOXIA n. a deficiency of oxygen in the body tissues, also HYPOXAEMIA, HYPOXEMIA.
OXYPHILSOXYPHIL n. an organism that thrives on an acid environment, also OXYPHILE.
PHENIXESphenixes n. Plural of phenix.
PHENIX n. a bird fabled to exist single, to be consumed by fire by its own act, and to rise again from its ashes, also PHOENIX.
PHYLAXISphylaxis n. (Medicine) Protection against infectious disease.
PHYLAXIS n. an inhibiting of infection by the body.
PIXIEISHpixieish adj. Alternative spelling of pixyish.
PIXIEISH adj. like a pixie.
RHEXISESRHEXIS n. (Greek) rupture of a blood vessel.
SIXTIETHsixtieth adj. The ordinal form of the number sixty.
sixtieth n. The person or thing in the sixtieth position.
sixtieth n. One of sixty equal parts of a whole.
SIXTYISHsixtyish adj. (Informal) Of about sixty years of age.
SIXTYISH adj. being about sixty years old.
SPHINXESsphinxes n. Plural of sphinx.
sphinxes v. Third-person singular simple present indicative form of sphinx.
SPHINX n. (Greek) any of several Egyptian stone figures of a creature with a human or animal head and (occasionally) breast and a lion's body.
VIXENISHvixenish adj. Of or pertaining to a vixen; resembling a vixen.
VIXENISH adj. bad-tempered, snarling.
XANTHINSxanthins n. Plural of xanthin.
XANTHIN n. a white substance, structurally related to uric acid, found in muscle tissue, the liver and other organs, also XANTHINE.
XANTHISMxanthism n. (Biology, zoology) A yellowish colouring of pigments in hair, skin, feathers, etc.
XANTHISM n. a condition of skin, fur or feathers in which yellow coloration predominates.
XIPHOIDSxiphoids n. Plural of xiphoid.
XIPHOID n. the xiphoid process or xiphisternum.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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