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There are 13 eight-letter words containing H, I, O and X

AMPHIOXIamphioxi n. Plural of amphioxus.
AMPHIOXUS n. (Greek) a fishlike creature, two or three inches long, found in temperate seas, aka lancelet.
ETHOXIDEethoxide n. (Chemistry) the anion CH3CH2O- derived from ethanol by the loss of a proton.
ethoxide n. (Chemistry) any salt of this anion.
ETHOXIDE n. a type of saltlike compound with metal and organic components, also ETHYLATE.
ETHOXIESethoxies n. Plural of ethoxy.
ETHOXY n. a univalent chemical radical, also ETHOXYL.
FOXSHIPSFOXSHIP n. (Shakespeare) craftiness.
HEXAFOILhexafoil n. A design with six round semicircular petals stemming from a central circle.
HEXAFOIL n. a pattern with six leaflike lobes.
HEXANOIChexanoic adj. Of or pertaining to hexanoic acid or its derivatives; caproic.
HEXANOIC adj. as in hexanoic acid, a component of palm oil.
HYPOXIAShypoxias n. Plural of hypoxia.
HYPOXIA n. a deficiency of oxygen in the body tissues, also HYPOXAEMIA, HYPOXEMIA.
OXYPHILEOXYPHILE n. an organism that thrives on an acid environment, also OXYPHIL.
OXYPHILSOXYPHIL n. an organism that thrives on an acid environment, also OXYPHILE.
PHORMINXphorminx n. A kind of lyre used by the Ancient Greeks.
PHORMINX n. (Greek) a kind of lyre used by the Greeks.
THYROXINthyroxin n. Alternative spelling of thyroxine.
THYROXIN n. an iodine compound, a hormone forming the active principle of the thyroid gland, also THYROXINE.
XENOLITHxenolith n. (Geology) any piece of rock having a different origin to that of the igneous rock in which it is found.
XENOLITH n. (Greek) a rock fragment foreign to the igneous mass in which it occurs.
XIPHOIDSxiphoids n. Plural of xiphoid.
XIPHOID n. the xiphoid process or xiphisternum.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the 1Word.ws and WikWik.org.

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