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There are 8 twelve-letter words containing F, 2L, R, S and 2U

CAULIFLOROUScauliflorous adj. (Botany) Having flowers on the stem.
CAULIFLOROUS adj. relating to cauliflory, the production of flowers on old stems from dormant buds.
FRUITFULLESTfruitfullest adj. Superlative form of fruitful: most fruitful.
FRUITFUL adj. productive.
MOURNFULLESTmournfullest adj. Superlative form of mournful: most mournful.
MOURNFUL adj. sad, grieving.
MULTIFLOROUSmultiflorous adj. (Botany) Having many flowers.
MULTIFLOROUS adj. many-flowered.
PURPOSEFULLYpurposefully adv. In a purposeful manner.
purposefully adv. (Proscribed) On purpose, purposely, deliberately.
PURPOSEFUL adv. showing purpose.
SCROFULOUSLYscrofulously adv. Morally degenerate; corrupt.
SCROFULOUS adv. afflicted with scrofula.
SULFONYLUREAsulfonylurea n. Any of a class of antidiabetic drugs that act by increasing insulin release from the beta cells in the…
SULFONYLUREA n. any of several hypoglycemic compounds related to the sulfonamides and used in the oral treatment of diabetes.
UNDERFULFILSUNDERFULFIL v. to fail to fulfil completely, also UNDERFULFILL.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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