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There are 3 twelve-letter words containing F, I, S and 3U

CIRCUMFLUOUScircumfluous adj. Circumfluent.
CIRCUMFLUOUS adj. flowing around, also CIRCUMFLUENT.
CUPULIFEROUScupuliferous adj. (Botany) Bearing, or furnished with, a cupule.
CUPULIFEROUS adj. bearing cupules.
FURUNCULOSISfurunculosis n. (Medicine) The presence of furuncles or boils.
FURUNCULOSIS n. an affliction of boils.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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