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There are 18 ten-letter words containing F, I, O, P and 2S

DISPROFESSdisprofess v. (Obsolete, rare) To give up, renounce.
DISPROFESS v. to renounce the profession or pursuit of.
DISPROFITSdisprofits v. Third-person singular simple present indicative form of disprofit.
DISPROFIT v. (archaic) to cause to fail to profit.
FLOPPINESSfloppiness n. The characteristic or quality of being floppy.
FLOPPINESS n. the state of being floppy.
OFFSPRINGSoffsprings n. Plural of offspring.
OFFSPRING n. progeny.
OPSONIFIESopsonifies v. Third-person singular simple present indicative form of opsonify.
OPSONIFY v. to form opsonins in, a substance of blood serum making bacteria vulnerable to phagocytic action.
PASSIFLORApassiflora n. (Botany) Any of the genus Passiflora of passionflowers.
Passiflora prop.n. A taxonomic genus within the family Passifloraceae – the passionflowers.
PASSIFLORA n. a genus of plants, including the passion flower.
PERFUSIONSperfusions n. Plural of perfusion.
PERFUSION n. the act of perfusing.
PROFASCISTprofascist adj. In favour of fascism.
profascist n. A supporter of fascism.
PROFASCIST adj. supporting fascism.
PROFESSINGprofessing v. Present participle of profess.
PROFESS v. to affirm openly.
PROFESSIONprofession n. Declaration of faith.
profession n. Professional occupation.
PROFESSION n. a calling.
PROFILISTSprofilists n. Plural of profilist.
PROFILIST n. one who draws profiles, also PROFILER.
PROFITLESSprofitless adj. Not yielding profit.
PROFITLESS adj. without profit.
PROFUSIONSprofusions n. Plural of profusion.
PROFUSION n. the state of being profuse.
SAPONIFIESsaponifies v. Third-person singular simple present indicative form of saponify.
SAPONIFY v. to convert into soap.
SOAPFISHESsoapfishes n. Plural of soapfish.
SOAPFISH n. a tropical fish that produces toxic mucus.
SOPORIFICSsoporifics n. Plural of soporific.
SOPORIFIC n. a drug producing sleep.
SPOILFIVESSPOILFIVE n. a certain game at cards in which, if no player wins three of the five tricks possible on any deal, the game is said to be spoiled.
SPOOFERIESspooferies n. Plural of spoofery.
SPOOFERY n. good-natured ridicule.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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