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There are 20 fifteen-letter words containing E, 2I, N, 3R and S

ANTIRETROVIRALSantiretrovirals n. Plural of antiretroviral.
ANTIRETROVIRAL n. any retroviral drug used to treat diseases caused by retroviruses, such as HIV.
ARBITRARINESSESarbitrarinesses n. Plural of arbitrariness.
ARBITRARINESS n. the state of being arbitrary.
EXTRAORDINARIESextraordinaries n. Plural of extraordinary.
extra-ordinaries n. Plural of extra-ordinary.
EXTRAORDINARY n. something out of the ordinary.
HERNIORRHAPHIESherniorrhaphies n. Plural of herniorrhaphy.
HERNIORRHAPHY n. the surgical repair of a hernia by an operation involving suturing.
INSURRECTIONARYinsurrectionary adj. Pertaining to, or characterized by, insurrection.
insurrectionary n. One who takes part in insurrection.
INSURRECTIONARY adj. relating to insurrection.
INTERPRETERSHIPinterpretership n. A qualification in interpreting.
interpretership n. The state of being an interpreter.
INTERPRETERSHIP n. the office of interpreter.
INTERROGATORIESinterrogatories n. Plural of interrogatory.
INTERROGATORY n. a question or interrogation.
IRREPREHENSIBLEirreprehensible adj. Not reprehensible, blameless, without blame; innocent.
IRREPREHENSIBLE adj. beyond blame.
IRREPREHENSIBLYirreprehensibly adv. In an irreprehensible manner.
IRREPREHENSIBLE adv. beyond blame.
MICROENTERPRISEmicroenterprise n. (Business) A very small business with five or fewer employees, or the business sector comprising these businesses.
MISINTERPRETERSmisinterpreters n. Plural of misinterpreter.
MISINTERPRETER n. one who misinterprets.
OVERPRESCRIBINGoverprescribing v. Present participle of overprescribe.
OVERPRESCRIBE v. to prescribe excessively.
PREREGISTRATIONpreregistration n. An early registration, before the normal or traditional time, as with early online check-in at hotels.
preregistration n. Registration (of a study design) before a clinical trial (or any other type of scientific experiment)…
preregistration adj. Before registration.
REREGISTRATIONSreregistrations n. Plural of reregistration.
REREGISTRATION n. the act of reregistering.
RESURRECTIONISEresurrectionise v. Alternative form of resurrectionize.
RESURRECTIONISE v. to bring about resurrection, also RESURRECTIONIZE.
RESURRECTIONISMresurrectionism n. Belief in, or the event of, a person being resurrected from the dead.
resurrectionism n. (Historical) Graverobbing.
RESURRECTIONISM n. belief in the Resurrection.
RESURRECTIONISTresurrectionist n. (Euphemistic, historical) One who sells cadavers to anatomists, surgeons, etc., especially by exhuming…
resurrectionist n. (Religion) A believer in a future bodily resurrection.
resurrectionist n. One who resurrects an abandoned idea, practice, etc.; a revivalist.
RESURRECTIONIZEresurrectionize v. (Transitive) To resurrect, or raise from the dead.
resurrectionize v. To remove a body from its grave (illegally, for dissection); to engage in bodysnatching.
RESURRECTIONIZE v. to bring about resurrection, also RESURRECTIONISE.
RIVERWORTHINESSriverworthiness n. The quality of being riverworthy.
RIVERWORTHINESS n. the state of being riverworthy.
TRINITROCRESOLStrinitrocresols n. Plural of trinitrocresol.
TRINITROCRESOL n. a yellow crystalline highly explosive compound.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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