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There are 14 twelve-letter words containing E, 2I, L, 2S, T and Y

DISLOYALTIESdisloyalties n. Plural of disloyalty.
DISLOYALTY n. lack of loyalty.
DISPITEOUSLYdispiteously adv. In a dispiteous manner.
DISPITEOUS adv. (obsolete) pitiless, malicious.
DISSENTINGLYdissentingly adv. With dissent or disagreement.
DISSENTING adv. DISSENT, to disagree.
DISSIPATEDLYdissipatedly adv. In a dissipated manner.
DISSIPATED adv. DISSIPATE, to scatter or disperse.
ESSENTIALITYessentiality n. The condition of being essential; a basic set of essential traits; being.
essentiality n. An essential thing.
ESSENTIALITY n. the state of being essential.
IRRESISTABLYirresistably adv. Dated form of irresistibly.
IRRESISTIBLYirresistibly adv. In an irresistible manner.
IRRESISTIBLE adv. impossible to resist.
LARYNGITISESLARYNGITIS n. inflammation of the larynx.
LITERARYISMSliteraryisms n. Plural of literaryism.
LITERARYISM n. a bookish expression.
PERSISTINGLYpersistingly adv. With persistence.
PERSISTING adv. PERSIST, to continue resolutely.
PROPYLITISESPROPYLITISE v. to become or turn into propylite, also PROPYLITIZE.
SEMIMYSTICALsemimystical adj. Somewhat or partially mystical.
SEMIMYSTICAL adj. having some of the qualities of mysticism.
SPIRITLESSLYspiritlessly adv. In a spiritless manner.
SPIRITLESS adv. lacking animation or courage.
STELLIFYINGSSTELLIFYING n. the act of turning into star.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the 1Word.ws and WikWik.org.

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See this list for:

  • English Wiktionary: 46 words
  • Scrabble in French: 11 words
  • Scrabble in Spanish: no word
  • Scrabble in Italian: no word
  • Scrabble in German: no word
  • Scrabble in Romanian: no word


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