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There are 12 words containing 3E, 2F, N, R and U

DEXFENFLURAMINEdexfenfluramine n. A serotonergic anorectic drug used for weight loss in the 1990s, later withdrawn because of cardiovascular…
EFFORTFULNESSESEFFORTFULNESS n. EFFORTFUL, requiring effort.
EQUIDIFFERENTequidifferent adj. Having equal differences.
EQUIDIFFERENT adj. having equal differences.
FEARFULNESSESfearfulnesses n. Plural of fearfulness.
FEARFULNESS n. the state of being fearful.
FORCEFULNESSESforcefulnesses n. Plural of forcefulness.
FORCEFULNESS n. the state of being forceful.
FORGETFULNESSESforgetfulnesses n. Plural of forgetfulness.
FORGETFULNESS n. the state of being forgetful.
FRETFULNESSESfretfulnesses n. Plural of fretfulness.
FRETFULNESS n. the state of being fretful.
SUFFERABLENESSsufferableness n. The state of being sufferable.
SUFFERABLENESS n. the state of being sufferable.
SUPEREFFICIENCYsuperefficiency n. The quality of being superefficient.
SUPEREFFICIENCY n. the state of being superefficient.
SUPEREFFICIENTsuperefficient adj. Very efficient.
SUPEREFFICIENT adj. extremely efficient.
UNDIFFERENCEDundifferenced adj. (Heraldry) Not having a mark of difference.
UNDIFFERENCED adj. not differenced.
UNRUFFLEDNESSESUNRUFFLEDNESS n. the state of being unruffled.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the 1Word.ws and WikWik.org.

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