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There are 3 words containing E, F, L and 4O

FLUOROQUINOLONEfluoroquinolone n. Any of a class of antibiotics (fluoro derivatives of quinolone) derived from nalidixic acid.
FOOTLOOSEfootloose adj. Tending to travel or do as one pleases; readily without many commitments or responsibility.
footloose adj. (Nautical) Of a sail: not properly secured at the bottom.
FOOTLOOSE adj. free or unhampered by (e.g. family) ties.
FOOTSTOOLEDfootstooled adj. Supplied with a footstool.
FOOTSTOOLED adv. with one's feet on a footstool.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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