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There are 20 words containing E, 2F, I, M and 2S

CAFFEISMSCAFFEISM n. an addiction to caffeine.
FILMFESTSFILMFEST n. a festival at which many films are shown.
MIFFINESSmiffiness n. The quality of being miffy, or easily irritated.
MIFFINESS n. the state of being miffy, quick to take offence.
SEMISTIFFSEMISTIFF adj. somewhat stiff.
DUFFERISMSDUFFERISM n. being a duffer, also DUFFERDOM.
CAFFEINISMSCAFFEINISM n. an unhealthy condition caused by taking too much caffeine.
EFFEMINISESeffeminises v. Third-person singular simple present indicative form of effeminise.
EFFEMINISE v. (archaic) to make effeminate, also EFFEMINIZE.
FRAMESHIFTSframeshifts n. Plural of frameshift.
FRAMESHIFT n. a term in genetic manipulation, a type of mutation.
MIFFINESSESMIFFINESS n. the state of being miffy, quick to take offence.
SHERIFFDOMSsheriffdoms n. Plural of sheriffdom.
SHERIFFDOM n. the office of sheriff.
SUFFUMIGATESsuffumigates v. Third-person singular simple present indicative form of suffumigate.
SUFFUMIGATE v. to fumigate from below.
EFFUSIOMETERSeffusiometers n. Plural of effusiometer.
EFFUSIOMETER n. an instrument for comparing the molecular weights of gases.
SEMIOFFICIALSSorry, definition not available.
SUFFRAGETTISMsuffragettism n. The suffragette movement for women’s voting rights.
SUFFRAGETTISM n. belief in the aims of the suffragette.
DISAFFIRMANCESdisaffirmances n. Plural of disaffirmance.
DISAFFIRMANCE n. the act of disaffirming.
EFFEMINATENESSeffeminateness n. Effeminacy.
EFFEMINATENESS n. the state of being effeminate.
SUFFRAGETTISMSSUFFRAGETTISM n. belief in the aims of the suffragette.
DISAFFORESTMENTdisafforestment n. Disafforestation.
DISAFFORESTMENT n. the act of disafforesting.
FORISFAMILIATESforisfamiliates v. Third-person singular simple present indicative form of forisfamiliate.
FORISFAMILIATE v. (Scots) to emancipate from parental authority.
INDIFFERENTISMSindifferentisms n. Plural of indifferentism.
INDIFFERENTISM n. the belief that all religions are equally valid.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the 1Word.ws and WikWik.org.

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