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There are 20 words containing E, 2F, I, M and 2S

CAFFEINISMSCAFFEINISM n. an unhealthy condition caused by taking too much caffeine.
CAFFEISMSCAFFEISM n. an addiction to caffeine.
DISAFFIRMANCESdisaffirmances n. Plural of disaffirmance.
DISAFFIRMANCE n. the act of disaffirming.
DISAFFORESTMENTdisafforestment n. Disafforestation.
DISAFFORESTMENT n. the act of disafforesting.
DUFFERISMSDUFFERISM n. being a duffer, also DUFFERDOM.
EFFEMINATENESSeffeminateness n. Effeminacy.
EFFEMINATENESS n. the state of being effeminate.
EFFEMINISESeffeminises v. Third-person singular simple present indicative form of effeminise.
EFFEMINISE v. (archaic) to make effeminate, also EFFEMINIZE.
EFFUSIOMETERSeffusiometers n. Plural of effusiometer.
EFFUSIOMETER n. an instrument for comparing the molecular weights of gases.
FILMFESTSFILMFEST n. a festival at which many films are shown.
FORISFAMILIATESforisfamiliates v. Third-person singular simple present indicative form of forisfamiliate.
FORISFAMILIATE v. (Scots) to emancipate from parental authority.
FRAMESHIFTSframeshifts n. Plural of frameshift.
FRAMESHIFT n. a term in genetic manipulation, a type of mutation.
INDIFFERENTISMSindifferentisms n. Plural of indifferentism.
INDIFFERENTISM n. the belief that all religions are equally valid.
MIFFINESSmiffiness n. The quality of being miffy, or easily irritated.
MIFFINESS n. the state of being miffy, quick to take offence.
MIFFINESSESMIFFINESS n. the state of being miffy, quick to take offence.
SEMIOFFICIALSSorry, definition not available.
SEMISTIFFSEMISTIFF adj. somewhat stiff.
SHERIFFDOMSsheriffdoms n. Plural of sheriffdom.
SHERIFFDOM n. the office of sheriff.
SUFFRAGETTISMsuffragettism n. The suffragette movement for women’s voting rights.
SUFFRAGETTISM n. belief in the aims of the suffragette.
SUFFRAGETTISMSSUFFRAGETTISM n. belief in the aims of the suffragette.
SUFFUMIGATESsuffumigates v. Third-person singular simple present indicative form of suffumigate.
SUFFUMIGATE v. to fumigate from below.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the 1Word.ws and WikWik.org.

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