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There are 12 words containing 2E, 3O, S and X

ECONOBOXESeconoboxes n. Plural of econobox.
ECONOBOX n. a small economical car.
HOMEOBOXEShomeoboxes n. Plural of homeobox.
HOMEOBOX n. a short DNA sequence, also HOMOEOBOX.
LOOSEBOXESlooseboxes n. Plural of loosebox.
loose-boxes n. Plural of loose-box.
loose␣boxes n. Plural of loose box.
EXOBIOLOGIESexobiologies n. Plural of exobiology.
EXOBIOLOGY n. the study of extraterrestrial life.
GOOGOLPLEXESgoogolplexes n. Plural of googolplex.
GOOGOLPLEX n. the figure 1 followed by a googol of zeroes (10 raised to the googol power).
DEOXYCORTONESDEOXYCORTONE n. a corticosteroid hormone important in maintaining sodium and water balance in the body.
NEOORTHODOXIESNEOORTHODOXY n. reactionaryism.
ORTHOPYROXENESorthopyroxenes n. Plural of orthopyroxene.
ORTHOPYROXENE n. a member of the pyroxene group of minerals having an orthorhombic crystal structure, such as enstatite and hypersthene.
SEROTAXONOMIESSEROTAXONOMY n. serological analysis as a source of information for taxonomic classification.
CHEMOTAXONOMIESchemotaxonomies n. Plural of chemotaxonomy.
CHEMOTAXONOMY n. the classification of plants and animals based on similarities and differences in biochemical composition.
ECOTOXICOLOGIESECOTOXICOLOGY n. the study of the destructive effect of waste materials, etc. on the environment.
OBNOXIOUSNESSESobnoxiousnesses n. Plural of obnoxiousness.
OBNOXIOUSNESS n. the state of being obnoxious.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the 1Word.ws and WikWik.org.

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