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There are 20 words containing 2E, 2F, 2I and O

COEFFICIENTcoefficient adj. Cooperating.
coefficient n. (Mathematics) A constant by which an algebraic term is multiplied.
coefficient n. A number, value, or item that serves as a measure of some property or characteristic.
INOFFENSIVEinoffensive adj. Not offensive.
inoffensive adj. Harmless.
INOFFENSIVE adj. causing no harm or injury, also UNOFFENSIVE.
INTEROFFICEinteroffice adj. Taking place between different offices of a single organization or company.
interoffice v. To send something between different offices in an organization.
INTEROFFICE adj. between offices.
OFFICIALESEofficialese n. The typical language of officials or official documents; legalistic and pompous language.
OFFICIALESE n. the characteristic language of official statements.
REFORTIFIEDrefortified v. Simple past tense and past participle of refortify.
REFORTIFY v. to fortify anew.
REFORTIFIESrefortifies v. Third-person singular simple present indicative form of refortify.
REFORTIFY v. to fortify anew.
COEFFICIENTScoefficients n. Plural of coefficient.
coëfficients n. Plural of coëfficient.
COEFFICIENT n. any of the factors of a product considered in relation to a specific factor.
INTEROFFICESinteroffices v. Third-person singular simple present indicative form of interoffice.
OFFICIALESESofficialeses n. Plural of officialese.
OFFICIALESE n. the characteristic language of official statements.
FORESIGNIFIEDforesignified v. Simple past tense and past participle of foresignify.
FORESIGNIFY v. (archaic) to signify in advance.
FORESIGNIFIESforesignifies v. Third-person singular simple present indicative form of foresignify.
FORESIGNIFY v. (archaic) to signify in advance.
INOFFENSIVELYinoffensively adv. In an inoffensive manner.
INOFFENSIVE adv. causing no harm or injury, also UNOFFENSIVE.
DIFFERENTIATORdifferentiator n. Anything that differentiates, or causes differentiation (in any sense); a distinguishing feature.
DIFFERENTIATOR n. someone who or that which differentiates.
DIFFERENTIATIONdifferentiation n. The act or process of differentiating (generally, without a specialized sense).
differentiation n. (Biology) The process by which the components of multicellular life (Cells, organs, etc.) are produced…
differentiation n. (Biology, evolution) The evolutionary process by which one taxonomic group (Species, genus, variety…
DIFFERENTIATORSdifferentiators n. Plural of differentiator.
DIFFERENTIATOR n. someone who or that which differentiates.
DISAFFECTIONATEdisaffectionate adj. Not disposed to affection; unfriendly.
DISAFFECTIONATE adj. showing disaffection.
EFFICACIOUSNESSefficaciousness n. Quality of being efficacious.
EFFICACIOUS n. having the power to produce a desired effect.
INOFFENSIVENESSinoffensiveness n. The state or condition of being inoffensive.
INOFFENSIVE n. causing no harm or injury, also UNOFFENSIVE.
OFFICIOUSNESSESofficiousnesses n. Plural of officiousness.
OFFICIOUSNESS n. OFFICIOUS, volunteering one's services too eagerly.
SCHIZOAFFECTIVEschizoaffective adj. (Psychiatry) Combining the symptoms of schizophrenia with those of bipolar disorder.
schizoaffective n. A person who has a schizoaffective disorder.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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