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There are 17 words containing 4E, 2F and R

EFFERENCEefference n. (Uncountable) The state of being efferent.
efference n. (Countable) An efferent process.
EFFERENCE n. the act of conveying outward or away.
EFFERENCESefferences n. Plural of efference.
EFFERENCE n. the act of conveying outward or away.
EFFERVESCEeffervesce v. (Intransitive, of a liquid) To emit small bubbles of dissolved gas; to froth or fizz.
effervesce v. (Intransitive, of a gas) To escape from solution in a liquid in the form of bubbles.
effervesce v. (Intransitive, of a person) To show high spirits.
EFFERVESCEDeffervesced v. Simple past tense and past participle of effervesce.
EFFERVESCE v. to bubble, hiss, and foam as gas escapes.
EFFERVESCESeffervesces v. Third-person singular simple present indicative form of effervesce.
EFFERVESCE v. to bubble, hiss, and foam as gas escapes.
EFFERVESCENTeffervescent adj. (Of a liquid) Giving off bubbles; fizzy.
effervescent adj. Vivacious and enthusiastic.
EFFERVESCENT adj. frothing, bubbling.
EFFERVESCENCEeffervescence n. The escape of gas from solution in a liquid, especially the escape of carbon dioxide from a carbonated drink.
effervescence n. Vivacity.
effervescence n. Foment.
EFFERVESCENCYeffervescency n. (Archaic) effervescence.
EFFERVESCENCY n. boiling or bubbling, also EFFERVESCENCE.
EFFERVESCIBLEeffervescible adj. Capable of effervescing.
EFFERVESCIBLE adj. capable of effervescing.
EFFLORESCENCEefflorescence n. (Chemistry) The formation of a powdery surface on crystals, as a hydrate is converted to anhydrous form…
efflorescence n. (Botany) The production of flowers.
efflorescence n. (Construction) An encrustation of soluble salts, commonly white, deposited on the surface of stone…
EFFERVESCENCESeffervescences n. Plural of effervescence.
EFFERVESCENCE n. boiling or bubbling, also EFFERVESCENCY.
EFFERVESCENTLYeffervescently adv. In an effervescent manner.
EFFERVESCENT adv. frothing, bubbling.
EFFLORESCENCESefflorescences n. Plural of efflorescence.
EFFLORESCENCE n. the act of developing and unfolding as if coming into flower.
SUPEREFFECTIVEsupereffective adj. Particularly effective.
SUPEREFFECTIVE adj. extremely effective.
DEDIFFERENTIATEdedifferentiate v. To lose or reverse differentiation.
DEDIFFERENTIATE v. to effect dedifferentiation, a change by which specialized tissue with several cell types reverts to a generalized and simpler form.
DIFFERENTNESSESdifferentnesses n. Plural of differentness.
DIFFERENTNESS n. DIFFERENT, separate, unlike.
EFFERVESCENCIESeffervescencies n. Plural of effervescency.
EFFERVESCENCY n. boiling or bubbling, also EFFERVESCENCE.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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