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There are 13 words containing 4E, 2F and I

AFFECTIVENESSES	• AFFECTIVENESS n. the state of being affective.
DEDIFFERENTIATE	• dedifferentiate v. To lose or reverse differentiation. • DEDIFFERENTIATE v. to effect dedifferentiation, a change by which specialized tissue with several cell types reverts to a generalized and simpler form.
DIFFERENTNESSES	• differentnesses n. Plural of differentness. • DIFFERENTNESS n. DIFFERENT, separate, unlike.
EFFECTIVENESS	• effectiveness n. The property of being effective, of achieving results. • effectiveness n. The capacity or potential for achieving results. • effectiveness n. The degree to which something achieves results.
EFFECTIVENESSES	• effectivenesses n. Plural of effectiveness. • EFFECTIVENESS n. the state of being effective.
EFFEMINATENESS	• effeminateness n. Effeminacy. • EFFEMINATENESS n. the state of being effeminate.
EFFERVESCENCIES	• effervescencies n. Plural of effervescency. • EFFERVESCENCY n. boiling or bubbling, also EFFERVESCENCE.
EFFERVESCIBLE	• effervescible adj. Capable of effervescing. • EFFERVESCIBLE adj. capable of effervescing.
EFFUSIVENESSES	• effusivenesses n. Plural of effusiveness. • EFFUSIVENESS n. the state of being effusive.
INEFFABLENESSES	• INEFFABLENESS n. the state of being ineffable.
INEFFECTIVENESS	• ineffectiveness n. The condition of being ineffective. • INEFFECTIVENESS n. the state of being ineffective.
OFFENSIVENESSES	• offensivenesses n. Plural of offensiveness. • OFFENSIVENESS n. the state of being offensive.
SUPEREFFECTIVE	• supereffective adj. Particularly effective. • SUPEREFFECTIVE adj. extremely effective.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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English Wiktionary: 314 words
Scrabble in French: 86 words
Scrabble in Spanish: no word
Scrabble in Italian: 116 words
Scrabble in German: no word
Scrabble in Romanian: 6 words

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