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There are 18 eight-letter words containing E, 2I, R, S and 2T

DIRTIESTdirtiest adj. Superlative form of dirty: most dirty.
dirtiest v. (Archaic) second-person singular simple present form of dirty.
DIRTY adj. soiled.
METRITISmetritis n. (Medicine) Inflammation of the uterus.
METRITIS n. inflammation of the uterus.
NITRITESnitrites n. Plural of nitrite.
NITRITE n. a salt of nitrous acid.
RECTITISrectitis n. (Medicine) proctitis.
RECTITIS n. inflammation of the rectum.
RIFTIESTRIFTY adj. having fissures.
RISPETTIrispetti n. Plural of rispetto.
RISPETTO n. (Italian) a type of Italian folksong with 8-line stanzas.
RITZIESTritziest adj. Superlative form of ritzy: most ritzy.
RITZY adj. pretentious.
SHITTIERshittier adj. (Vulgar) comparative form of shitty: more shitty.
SHITTY adj. (vulgar) very unpleasant.
SLITTIERslittier adj. Comparative form of slitty: more slitty.
SLITTY adj. of an opening, long and narrow.
SNITTIERsnittier adj. Comparative form of snitty: more snitty.
SNITTY adj. disagreeably ill-tempered.
SPITTIERSPITTY adj. marked with saliva.
STILTIERstiltier adj. Comparative form of stilty: more stilty.
STILTY adj. stilt-like.
STINTIERSTINTY adj. limited.
THIRTIESthirties n. Plural of thirty.
thirties n. A decade starting with the year xx30, most usually the decade from 1930 to 1939.
thirties n. The decade of one’s life from age 30 through age 39.
TRIPIESTTRIPY adj. like tripe, worthless, also TRIPEY.
TRITIDEStritides n. Plural of tritide.
TRITIDE n. a compound of tritium.
TWISTIERtwistier adj. Comparative form of twisty: more twisty.
TWISTY adj. full of curves.
UTERITISuteritis n. Synonym of metritis.
UTERITIS n. inflammation of the womb.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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