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There are 3 eight-letter words containing E, 2I, N, 2P and R

PIPERINEpiperine n. (Organic chemistry) The alkaloid responsible for the pungency of black pepper.
PIPERINE n. an alkaloid found in black pepper.
PRINCIPEPrincipe prop.n. A surname.
Príncipe prop.n. An island which forms part of São Tomé and Príncipe.
PRINCIPE n. (Italian) a prince.
SNIPPIERsnippier adj. Comparative form of snippy: more snippy.
SNIPPY adj. stingy, snappish.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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