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There are 11 eight-letter words containing 2E, N, P, R and 2S

EREPSINSerepsins n. Plural of erepsin.
EREPSIN n. an enzyme of the small intestine.
PENSTERSpensters n. Plural of penster.
PENSTER n. a writer.
PERTNESSpertness n. The quality of being pert; cheekiness, impudence.
pertness n. The quality of being pert; firmness (usually of breasts).
PERTNESS n. the quality of being pert.
PRESENTSpresents n. Plural of present.
presents n. (Law) The document in which the word presents appears.
presents v. Third-person singular simple present indicative form of present.
PRESSMENpressmen n. Plural of pressman.
PRESSMAN n. a printing press operator.
PURENESSpureness n. The quality of being pure; purity.
PURENESS n. the quality of being pure.
RESPONSEresponse n. An answer or reply, or something in the nature of an answer or reply.
response n. The act of responding or replying; reply: as, to speak in response to a question.
response n. An oracular answer.
RIPENESSripeness n. The characteristic of being ripe.
RIPENESS n. the state of being ripe.
SERPENTSserpents n. Plural of serpent.
serpents v. Third-person singular simple present indicative form of serpent.
SERPENT n. a snake.
SPENCERSspencers n. Plural of spencer.
SPENCER n. one who has the care of the spence, or buttery.
SPENDERSspenders n. Plural of spender.
SPENDER n. one who spends.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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