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There are 4 eight-letter words containing 2E, N, 2O, S and T

ECOTONESecotones n. Plural of ecotone.
ECOTONE n. a transition area between two adjacent ecological communities.
OESTRONEoestrone n. (British spelling, biochemistry, steroids) Alternative spelling of estrone.
œstrone n. Obsolete typography of oestrone.
OESTRONE n. an estrogen, also ESTRIN, ESTRONE, OESTRIN.
OSTEOGENosteogen n. (Physiology) The soft tissue, or substance, which, in developing bone, ultimately undergoes ossification.
OSTEOGEN n. a substance from which bone is formed.
ROESTONEroestone n. (Mineralogy) oolite.
ROESTONE n. another name for oolite, a kind of limestone comprising small egg-like grains.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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