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There are 7 eight-letter words containing 2E, M, N, 2O and S

ENDOSOMEendosome n. (Biology) An endocytic vacuole through which molecules internalized during endocytosis pass en route to lysosomes.
ENDOSOME n. a cellular particle.
LONESOMElonesome adj. Unhappy due to being alone; lonely.
lonesome n. (Informal) Oneself alone.
LONESOME adj. lonely.
MOONEYESmooneyes n. Plural of mooneye.
moon␣eyes n. Plural of moon eye.
moon␣eyes n. (Informal) A romantic look at someone; goo-goo eyes.
MOONSEEDmoonseed n. A twining plant of the genera Menispermum or Cocculus, in the family Menispermaceae.
MOONSEED n. a plant of genus Menispermum with lunate seeds.
MOONSHEEmoonshee n. Archaic spelling of munshi.
MOONSHEE n. (Hindi) a secretary, interpreter, also MUNSHI.
OENOMELSOENOMEL n. (Greek) an ancient Greek beverage, also OINOMEL.
SOMEONESsomeones n. Plural of someone.
someone's pron. Possessive case of someone.
someone's cont. Someone is.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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