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There are 5 fifteen-letter words containing 2E, I, 3M and S

IMMUNOCOMPLEXESimmunocomplexes n. Plural of immunocomplex.
IMMUNOCOMPLEX n. a complex formed between an antibody and an antigen.
METAMATHEMATICSmetamathematics n. A branch of mathematics dealing with mathematical systems and their nature.
METAMATHEMATICS n. a field of study concerned with the formal structure and properties (as the consistency and completeness of axioms) of mathematical systems.
MISIMPROVEMENTSmisimprovements n. Plural of misimprovement.
MISIMPROVEMENT n. a false improvement.
MISMEASUREMENTSmismeasurements n. Plural of mismeasurement.
MISMEASUREMENT n. wrong measurement.
OVERCOMMITMENTSovercommitments n. Plural of overcommitment.
OVERCOMMITMENT n. excessive commitment.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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