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There are 18 fifteen-letter words containing 2E, 2F, 2I and N

DEDIFFERENTIATEdedifferentiate v. To lose or reverse differentiation.
DEDIFFERENTIATE v. to effect dedifferentiation, a change by which specialized tissue with several cell types reverts to a generalized and simpler form.
DIFFERENTIATINGdifferentiating v. Present participle of differentiate.
DIFFERENTIATE v. to obtain the mathematical derivative of.
DIFFERENTIATIONdifferentiation n. The act or process of differentiating (generally, without a specialized sense).
differentiation n. (Biology) The process by which the components of multicellular life (Cells, organs, etc.) are produced…
differentiation n. (Biology, evolution) The evolutionary process by which one taxonomic group (Species, genus, variety…
DIFFERENTIATORSdifferentiators n. Plural of differentiator.
DIFFERENTIATOR n. someone who or that which differentiates.
DIFFRACTIVENESSDIFFRACTIVE n. causing diffraction.
DIFFUSIVENESSESdiffusivenesses n. Plural of diffusiveness.
DIFFUSIVENESS n. the state of being diffusive.
DISAFFECTIONATEdisaffectionate adj. Not disposed to affection; unfriendly.
DISAFFECTIONATE adj. showing disaffection.
EFFICACIOUSNESSefficaciousness n. Quality of being efficacious.
EFFICACIOUS n. having the power to produce a desired effect.
HYPEREFFICIENCYSorry, definition not available.
INDIFFERENTISMSindifferentisms n. Plural of indifferentism.
INDIFFERENTISM n. the belief that all religions are equally valid.
INDIFFERENTISTSindifferentists n. Plural of indifferentist.
INDIFFERENTIST n. an exponent of indifferentism.
INEFFACEABILITYineffaceability n. Quality of being ineffaceable.
INEFFACEABILITY n. the state of being ineffaceable.
INEFFECTIVENESSineffectiveness n. The condition of being ineffective.
INEFFECTIVENESS n. the state of being ineffective.
INOFFENSIVENESSinoffensiveness n. The state or condition of being inoffensive.
INOFFENSIVE n. causing no harm or injury, also UNOFFENSIVE.
INSUFFICIENCIESinsufficiencies n. Plural of insufficiency.
INSUFFICIENCY n. the state of being insufficient, also INSUFFICIENCE.
OFFICIOUSNESSESofficiousnesses n. Plural of officiousness.
OFFICIOUSNESS n. OFFICIOUS, volunteering one's services too eagerly.
SUFFICINGNESSESSUFFICINGNESS n. the state of being sufficing.
SUPEREFFICIENCYsuperefficiency n. The quality of being superefficient.
SUPEREFFICIENCY n. the state of being superefficient.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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