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There are 7 twelve-letter words containing E, S, 3T and 2U

AUTODESTRUCTautodestruct v. (Intransitive, chiefly science fiction) To destroy itself by design (as of a mechanical system).
autodestruct n. (Chiefly science fiction) A feature of a system whereby it destroys itself.
AUTODESTRUCT v. to self-destruct.
SCUTTLEBUTTSscuttlebutts n. Plural of scuttlebutt.
scuttle-butts n. Plural of scuttle-butt.
SCUTTLEBUTT n. a drinking fountain on a ship; gossip.
SKUTTERUDITEskutterudite n. (Mineralogy) A class of mixed cobalt and nickel arsenide and sulfide minerals.
SKUTTERUDITE n. a cubic mineral, cobalt arsenide.
SUBSTITUENTSsubstituents n. Plural of substituent.
SUBSTITUENT n. a thing, esp. an atom, substituted for another.
SUBSTITUTIVEsubstitutive adj. Characteristic of, or serving as a substitute.
SUBSTITUTIVE adj. serving or suitable as a substitute.
TRUSTBUSTERStrustbusters n. Plural of trustbuster.
TRUSTBUSTER n. a person who works for or achieves the breakup of business trusts, e.g. by legislation.
UNSTATUTABLEunstatutable adj. Not statutable.
UNSTATUTABLE adj. contrary to statute.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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