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There are 4 twelve-letter words containing E, L, 2S, 2T and X

EXISTENTIALSexistentials n. Plural of existential.
EXISTENTIAL n. an existential statement or formula.
EXPOSTULATESexpostulates v. Third-person singular simple present indicative form of expostulate.
EXPOSTULATE v. to remonstrate; to discuss or reason with.
EXTERNALISTSexternalists n. Plural of externalist.
EXTERNALIST n. a believer in externalism.
EXTRASYSTOLEextrasystole n. (Medicine) A premature contraction of the heart, producing an interruption or irregularity in heartbeat…
EXTRASYSTOLE n. a premature beat of one of the chambers of the heart that leads to momentary arrhythmia.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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