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There are 6 twelve-letter words containing E, L, 2M, O, P and U

LITHOSPERMUMlithospermum n. (Botany) Any plant of the genus Lithospermum.
Lithospermum prop.n. A taxonomic genus within the family Boraginaceae – the stoneseeds and gromwells.
LITHOSPERMUM n. a kind of flower.
LUMPECTOMIESlumpectomies n. Plural of lumpectomy.
LUMPECTOMY n. the surgical removal of a lump, esp. in the breast, aka tylectomy.
MULTIPROBLEMmultiproblem adj. Involving more than one problem.
MULTIPROBLEM adj. featuring many problems.
PAMPELMOUSESpampelmouses n. Plural of pampelmouse.
PAMPELMOUSE n. (Dutch) the shaddock or grapefruit, also PAMPELMOOSE, POMELO, POMPELMOOSE, POMPELMOUS, POMPELMOUSE, POMPELO, PUMELO, PUMMELO.
POMPELMOUSESpompelmouses n. Plural of pompelmous.
pompelmouses n. Plural of pompelmouse.
POMPELMOUSE n. (Dutch) the shaddock or grapefruit, also PAMPELMOOSE, PAMPELMOUSE, POMELO, POMPELMOOSE, POMPELMOUS, POMPELO, PUMELO, PUMMELO.
UNEMPLOYMENTunemployment n. The state of having no job; joblessness.
unemployment n. The phenomenon of joblessness in an economy.
unemployment n. The level of joblessness in an economy, often measured as a percentage of the workforce.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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