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There are 6 twelve-letter words containing 2E, 2N, P and 2U

SUPERANNUATEsuperannuate v. (Transitive) To retire or put out of use due to age.
superannuate v. (Transitive) To show to be obsolete due to age.
superannuate v. (Intransitive) To retire due to age.
SUPERMUNDANEsupermundane adj. Above or beyond the mundane.
SUPERMUNDANE adj. above worldly things.
UNEXPUGNABLEunexpugnable adj. That cannot be expugned; safe from attack.
UNEXPUGNABLE adj. not expugnable.
UNSUPPLENESSunsuppleness n. The quality of not being supple.
UNSUPPLENESS n. the state of being unsupple.
VENEPUNCTUREvenepuncture n. Alternative spelling of venipuncture.
VENEPUNCTURE n. the puncturing of a vein with a hypodermic needle, to draw off a sample of blood, also VENIPUNCTURE.
VENIPUNCTUREvenipuncture n. (Hematology) The puncture of a vein, usually to draw a blood sample, collect a blood donation, or insert…
venipuncture v. To puncture a vein in order to collect blood; to perform venipuncture.
VENIPUNCTURE n. the puncturing of a vein with a hypodermic needle, to draw off a sample of blood, also VENEPUNCTURE.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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