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There are 20 twelve-letter words containing 2E, M, 3O and S

COMETOLOGIESCOMETOLOGY n. the study of comets.
DEMONOLOGIESdemonologies n. Plural of demonology.
DEMONOLOGY n. the study of demons.
ENTOMOLOGIESENTOMOLOGY n. the study of insects.
ENTOMOLOGISEentomologise v. Alternative spelling of entomologize.
ENTOMOLOGISE v. to practise entomology, also ENTOMOLOGIZE.
GEOECONOMICSgeoeconomics n. The study of the spatial, temporal, and political aspects of economies and resources in relation to…
HETERONOMOUSheteronomous adj. Arising from an external influence, force, or agency; not autonomous.
heteronomous adj. (Biology, of parts of an organism) Differing in development or in specialization.
heteronomous adj. (Linguistics, of a language) Being a dialect of an autonomous language.
HOMESCHOOLEDhomeschooled v. Simple past tense and past participle of homeschool.
home␣schooled v. Simple past tense and past participle of home school.
HOMESCHOOL v. to teach school subjects to one's children at home.
HOMESCHOOLERhomeschooler n. One who homeschools a student (typically the parent).
homeschooler n. A student who is homeschooled, a homeschooled student.
home-schooler n. Alternative form of homeschooler.
HOMOEOMERIEShomoeomeries n. Plural of homoeomery.
HOMOEOMERY n. the state of being homoeomeric, having all the somites alike, also HOMEOMERY.
HOMOEOMEROUShomoeomerous adj. (Biology) Having similar quantities or variations pertaining to parts of structure.
homoeomerous adj. Being the same whether whole or divided into parts.
homœomerous adj. Obsolete form of homoeomerous.
HOMOEOSTASESHOMOEOSTASIS n. a tendency towards health or stable physical conditions, also HOMEOSTASIS.
HOMOEOTHERMShomoeotherms n. Plural of homoeotherm.
HOMOEOTHERM n. an animal or organism that keeps its body at an almost constant temperature, also HOMEOTHERM, HOMOIOTHERM.
HONEYMOONERShoneymooners n. Plural of honeymooner.
HONEYMOONER n. one who is on honeymoon.
MONOPTEROSESMONOPTEROS n. a building with single ring of columns supporting a roof.
OSTEODERMOUSOSTEODERMOUS adj. of or like an osteoderm, also OSTEODERMAL, OSTEODERMATOUS, OSTEODERMIC.
OVERPROMOTESoverpromotes v. Third-person singular simple present indicative form of overpromote.
OVERPROMOTE v. to promote excessively.
POMPELMOOSESpompelmooses n. Plural of pompelmoose.
POMPELMOOSE n. (Dutch) the shaddock or grapefruit, also PAMPELMOOSE, PAMPELMOUSE, POMELO, POMPELMOUS, POMPELMOUSE, POMPELO, PUMELO, PUMMELO.
PSEUDOCOELOMpseudocoelom n. Synonym of pseudocoel.
TELEOSTOMOUSTELEOSTOMOUS adj. belonging to the Teleostomi, fishes with membrane bones in the skull.
TOMFOOLERIEStomfooleries n. Plural of tomfoolery.
TOMFOOLERY n. playful or foolish behavior.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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