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There are 6 twelve-letter words containing 2E, 2M, P, T and U

EMPYREUMATICempyreumatic adj. (Obsolete, chemistry) Characteristic of empyreuma.
EMPYREUMATIC adj. relating to empyreuma, also EMPYREUMATICAL.
LUMPECTOMIESlumpectomies n. Plural of lumpectomy.
LUMPECTOMY n. the surgical removal of a lump, esp. in the breast, aka tylectomy.
METACOMPUTERMETACOMPUTER n. a collection of computers that looks and functions like a single computer.
MUMBLETYPEGSMUMBLETYPEG n. a game of throwing knives to make them stick in the ground.
SEMPITERNUMSsempiternums n. Plural of sempiternum.
SEMPITERNUM n. (obsolete) a durable woollen cloth.
UNEMPLOYMENTunemployment n. The state of having no job; joblessness.
unemployment n. The phenomenon of joblessness in an economy.
unemployment n. The level of joblessness in an economy, often measured as a percentage of the workforce.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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