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There are 10 ten-letter words containing E, M, 3O and 2S

HOUSEROOMShouserooms n. Plural of houseroom.
HOUSEROOM n. room or place in a house; as, to give any one houseroom.
MONOSOMIESmonosomies n. Plural of monosomy.
MONOSOMY n. a condition of having one unpaired chromosome.
MOONSTONESmoonstones n. Plural of moonstone.
MOONSTONE n. a nearly pellucid variety of feldspar, showing pearly or opaline reflections from within.
MOOSEWOODSmoosewoods n. Plural of moosewood.
MOOSEWOOD n. a North American tree, aka striped maple.
OSTEOTOMESosteotomes n. Plural of osteotome.
OSTEOTOME n. strong nippers or a chisel for dividing bone.
SENSOMOTORSENSOMOTOR adj. of or relating to both the sensory and motor functions of an organism or to the nerves controlling them.
SMOKEHOODSsmokehoods n. Plural of smokehood.
smoke␣hoods n. Plural of smoke hood.
SMOKEHOOD n. a protective hood for a firefighter that prevents the wearer from inhaling smoke.
SOPHOMORESsophomores n. Plural of sophomore.
SOPHOMORE n. a second year student in an American college.
STOREROOMSstorerooms n. Plural of storeroom.
STOREROOM n. a room in which things are stored.
WOODSMOKESwoodsmokes n. Plural of woodsmoke.
WOODSMOKE n. smoke produced by burning wood.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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