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There are 10 ten-letter words containing 2E, N, P, R and 2U

EPINEURIUMepineurium n. (Anatomy) The connective tissue framework and sheath of a nerve which bind together the nerve bundles…
EPINEURIUM n. the connective tissue framework and sheath of a nerve.
MUMPRENEURmumpreneur n. (Informal) A mother who works as a business entrepreneur in addition to her family commitments.
MUMPRENEUR n. a woman who combines running a business enterprise with looking after her children, also MOMPRENEUR.
PUBERULENTpuberulent adj. Covered in soft, downy hairs.
PUBERULENT adj. feebly or minutely pubescent; covered with minute down, also PUBERULOUS.
PURULENCESpurulences n. Plural of purulence.
PURULENCE n. the state of being purulent, also PURULENCY.
SUPERNURSEsupernurse n. An exceptionally talented or successful medical nurse.
SUPERNURSE n. a highly experienced nurse paid to remain in the field of direct patient care rather than seek promotion to a management post.
UNPERFUMEDunperfumed adj. Not perfumed.
UNPERFUMED adj. not perfumed.
UNPERJUREDunperjured adj. Not belied by perjury; genuine, honest.
UNPERJURED adj. not perjured.
UNPUCKEREDunpuckered v. Simple past tense and past participle of unpucker.
UNPUCKER v. to remove the wrinkles from.
UNPURVEYEDunpurveyed adj. (Archaic) unprovided.
UNPURVEYED adj. not purveyed, not provided with, also UNPURVAIDE.
UPSURGENCEUPSURGENCE n. the state of surging up e.g. an upsurgence of emotion.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the 1Word.ws and WikWik.org.

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