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There are 3 ten-letter words containing 2E, 2N, 2O and U

ENDOGENOUSendogenous adj. Produced, originating or growing from within.
endogenous adj. Of a natural process: caused by factors within the body.
ENDOGENOUS adj. produced or growing from within.
UNLOOSENEDunloosened v. Simple past tense and past participle of unloosen.
UNLOOSEN v. to set free, also UNLOOSE.
XENOGENOUSxenogenous adj. Of foreign origin; xenogenic.
xenogenous adj. (Pathology) Caused by a foreign body; originating outside the organism. Xenogenous caused by a foreign…
XENOGENOUS adj. due to an outside cause.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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