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There are 5 ten-letter words containing 2E, 2M, P and 2S

EMPHYSEMASemphysemas n. Plural of emphysema.
EMPHYSEMA n. a swelling produced by gas or air diffused in the cellular tissue.
EPIMERISMSEPIMERISM n. optical isomerism.
EUPHEMISMSeuphemisms n. Plural of euphemism.
EUPHEMISM n. a figure of rhetoric by which an unpleasant or offensive thing is described or referred to by a milder term.
MISTEMPERSmistempers v. Third-person singular simple present indicative form of mistemper.
MISTEMPER v. (obsolete) to temper ill; to disorder.
SEMIPLUMESsemiplumes n. Plural of semiplume.
SEMIPLUME n. a feather with an ordinary shaft but a downy web.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the 1Word.ws and WikWik.org.

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