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There are 10 words containing E, 2M, 2S and X

MAXIMISESmaximises v. Third-person singular simple present indicative form of maximise.
MAXIMISE v. to make as great as possible, also MAXIMIZE.
MAXIMUSESMAXIMUS n. a very long bell ringing sequence on twelve bells.
EXTREMISMSextremisms n. Plural of extremism.
EXTREMISM n. the taking of an extreme position.
MAXIMISERSmaximisers n. Plural of maximiser.
MAXIMISER n. one who maximises, also MAXIMIZER.
MIXMASTERSmixmasters n. Plural of mixmaster.
MIXMASTER n. a disc jockey.
HEXAMERISMSHEXAMERISM n. the state of being hexamerous.
MYXOMATOSESMYXOMATOSIS n. a fatal contagious disease of rabbits.
AXISYMMETRIESaxisymmetries n. Plural of axisymmetry.
AXISYMMETRY n. the state of being axisymmetric.
HOMOSEXUALISMhomosexualism n. (Dated) Homosexuality, the state of being homosexual.
homosexualism n. (Derogatory) A purported ideology behind (and promoting) homosexuality; gayness viewed as an ideology…
HOMOSEXUALISM n. being homosexual.
HOMOSEXUALISMSHOMOSEXUALISM n. being homosexual.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the 1Word.ws and WikWik.org.

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